Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis

Utilizing Micronutrients as a Chemopreventive Strategy for Prostate Cancer

Chemopreventive Effect of Aster glehni on Inflammation-Induced Colorectal Carcinogenesis in Mice

Although Aster glehni is a common dietary herb that has various bioactivities, including anti-diabetic, anti-adipogenic, and anti-inflammatory effects, A. glehni has not been studied in colon cancer. Therefore, we hypothesized the chemopreventive effects of an ethanol extract of A. glehni (AG) on azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis-associated cancer (CAC) in mice. In t...

Prostate carcinogenesis and inflammation: emerging insights.

Prostate cancer remains a significant health concern for men throughout the world. Recently, there has developed an expanding multidisciplinary body of literature suggesting a link between chronic inflammation and prostate cancer. In support of this hypothesis, population studies have found an increased relative risk of prostate cancer in men with a prior history of certain sexually transmitted...

Chemopreventive Intervention in Chemically-induced Carcinogenesis in Sub-saharan Africa

There is ample evidence that dietary factors can contribute to human cancer risk and as such many of the cancer common the sub-Saharan Africa including liver, colon, prostate and breast cancer have been related to dietary behaviors. In particular, hepatocellular carcinoma which is the fifth leading cause of cancer mortality in the world constitute a major health problem especially in the develo...

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

1Department of Pathology University of California, San Francisco, San Francisco, CA 94143, USA 2Helen Diller Family Comprehensive Cancer Center University of California, San Francisco, San Francisco, CA 94143, USA 3Angiogenesis and Tumor Targeting Research Unit, San Raffaele-Telethon Institute for Gene Therapy and Vita-Salute San Raffaele University, San Raffaele Institute, Milan, 20132, Italy ...